1. Add reference to COM object Microsoft.Office.Excel 12.0 or any other available library.
2. Code:
using Microsoft.Office.Interop.Excel;
private void anyfunction()
{
Microsoft.Office.Interop.Excel.Application xlapp = new Microsoft.Office.Interop.Excel.Application();
Microsoft.Office.Interop.Excel.Workbook xlWkb = null;
Microsoft.Office.Interop.Excel.Worksheet xlWks = null;
xlWkb = xlapp.Workbooks.Open(System.Windows.Forms.Application.StartupPath + @”Report.xls”, Missing.Value, false, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value, Missing.Value);
xlWks = (Microsoft.Office.Interop.Excel.Worksheet)xlWkb.Worksheets[1];
//Sample Statement to work on sheets
xlWks.get_Range(“A2”, “H65000”).ClearContents();
xlWkb.Close(true, Missing.Value, Missing.Value);
}